This state of the science document provides a judgment on the degree to which nonmonotonic dose-responses are evidenced in the scientific literature and evaluates the extent to which they may impact EPA’s chemical testing and risk assessment.
You will need Adobe Reader to view some of the files on this page. See EPA’s About PDF page to learn more.- EPA’s State of the Science Evaluation: Nonmonotonic Dose Responses as They Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures (Draft) (PDF)(178 pp, 3 MB)
- Appendix A: Mammalian Studies Describing the Effects of Chemicals That Disrupt the Estrogen Signaling Pathways (PDF)(92 pp, 2 MB)
- Appendix B: Mammalian Studies Describing the Effects of Chemicals That Disrupt the Androgen Signaling Pathways (PDF)(91 pp, 2 MB)
- Appendix C: Mammalian Studies Describing the Effects of Chemicals That Disrupt the Thyroid Signaling Pathways (PDF)(59 pp, 4 MB)
- Appendix D: Aquatic Ecotoxicology Studies (PDF)(15 pp, 544 K)