You will need Adobe Reader to view some of the files on this page. See EPA’s About PDF page to learn more.Substitutes are reviewed on the basis of environmental and health risks, including factors such as ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptableacceptableThis designation means that a substitute may be used, without restriction, to replace the relevant ODS within the end-use specified. For example, HCFC-22 is an acceptable substitute for R-502 in industrial process refrigeration. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. and unacceptableUnacceptableThis designation means that it is illegal to use a product as a substitute for an ODS in a specific end-use. For example, HCFC-141b is an unacceptable substitute for CFC-11 in building chillers. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. substitutes are updated several times each year. The list of acceptable substitutes are shown below.

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Substitute	Trade Name	Retrofit/New	ODPODPA number that refers to the amount of ozone depletion caused by a substance. The ODP is the ratio of the impact on ozone of a chemical compared to the impact of a similar mass of CFC-11. Thus, the ODP of CFC-11 is defined to be 1.0. Other CFCs and HCFCs have ODPs that range from 0.01 to 1.0. The halons have ODPs ranging up to 10. Carbon tetrachloride has an ODP of 1.2, and methyl chloroform's ODP is 0.11. HFCs have zero ODP because they do not contain chlorine. A table of all ozone-depleting substances (https://www3.epa.gov/ozone/science/ods/index.html) shows their ODPs, GWPs, and CAS numbers.	GWPGWPThe index used to translate the level of emissions of various gases into a common measure in order to compare the relative radiative forcing of different gases without directly calculating the changes in atmospheric concentrations. GWPs are calculated as the ratio of the radiative forcing that would result from the emissions of one kilogram of a greenhouse gas to that from the emission of one kilogram of carbon dioxide over a period of time (usually 100 years). Gases involved in complex atmospheric chemical processes have not been assigned GWPs. See lifetime.	ASHRAEASHRAEASHRAE is an international organization that establishes standards for the uniform testing and rating of heating, ventilation, air conditioning, and refrigeration equipment. It also conducts related research, disseminates publications, and provides continuing education to its members. Designation (Safety Classification)	SNAP Listing Date	Use Conditions
HFC-23		R/N	0	14,800	A1	August 26, 1994
HFC-245fa	Genetron® 245fa	R/N	0	1,030	A1	March 29, 2006
HFE-7000		R/N	0	575	A1	June 16, 2010
HFE-7100		N	0	297	A1	December 18, 2000; June 16, 2010	Only acceptable for use as a secondary heat transfer fluid in not-in-kind systems.
HFE-7200		N	0	59	N/A	December 18, 2000; June 16, 2010	Only acceptable for use as a secondary heat transfer fluid in not-in-kind systems.
ISCEON 89	ISCEON 89	R/N	0	3,792	A1	August 21, 2003
NARM-502		R/N	>0	N/A	A1	September 5, 1996
PFC-1102HC, PFC-662HC, PFC-552HC, and FLC-15		N	>0	N/A	A1	March 22, 2002
PFC-330ST, PFC-550HC, PFC-660HC, PFC-1100HC, PFC-1100LT, PGC-100, PGC-150, PFC-331ST, PFC-551HC, PFC-661HC, PFC-1101HC, and PGC-151		R/N	>0	N/A	N/A	May 23, 2001
R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5)	ICOR AT-22	R/N	0	2,530	A1	March 29, 2006
R-170 (Ethane)		N	0	5.5	A3	April 10, 2015	Detailed conditions apply - see Rule
R-290 (Propane)		N	0	3	A3	December 1, 2016	Detailed conditions apply - see Rule
R-403B	ISCEON 69-L	R/N	0.041	3,096	A1	August 26, 1994
R-404A	HP-62	R/N	0	3,920	A1	December 20, 2002
R-407C	Suva 407C, Klea 407C	R/N	0	1,770	A1	February 8, 1996; December 20, 2002
R-410A	AZ-20, Suva 9100, Puron	N	0	2,090	A1	February 8, 1996; December 20, 2002
R-410B		N	0	2,230	A1	February 8, 1996
R-422B	ICOR XAC1, NU-22B	R/N	0	2,530	A1	March 29, 2006
R-422C	ICOR XLT1	R/N	0	3,390	A1	March 29, 2006
R-507, R-507A	AZ-50	R/N	0	3,990	A1	December 20, 2002; October 4, 2011
R-508A (PFC Blend Alpha)	Klea 5R3	R/N	0	13,214	A1	July 28, 1995
R-508B	Suva 95	R/N	0	13,396	A1	July 28, 1995
R-744 (Carbon Dioxide, CO2)		R/N	0	1	A1	January 13, 1995; June 16, 2010

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