You will need Adobe Reader to view some of the files on this page. See EPA’s About PDF page to learn more.Substitutes are reviewed on the basis of environmental and health risks, including factors such as ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptableacceptableThis designation means that a substitute may be used, without restriction, to replace the relevant ODS within the end-use specified. For example, HCFC-22 is an acceptable substitute for R-502 in industrial process refrigeration. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. and unacceptableUnacceptableThis designation means that it is illegal to use a product as a substitute for an ODS in a specific end-use. For example, HCFC-141b is an unacceptable substitute for CFC-11 in building chillers. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. substitutes are updated several times each year. The list of acceptable substitutes are shown below.

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Substitute	Trade Name	Retrofit/New	ODPODPA number that refers to the amount of ozone depletion caused by a substance. The ODP is the ratio of the impact on ozone of a chemical compared to the impact of a similar mass of CFC-11. Thus, the ODP of CFC-11 is defined to be 1.0. Other CFCs and HCFCs have ODPs that range from 0.01 to 1.0. The halons have ODPs ranging up to 10. Carbon tetrachloride has an ODP of 1.2, and methyl chloroform's ODP is 0.11. HFCs have zero ODP because they do not contain chlorine. A table of all ozone-depleting substances (https://www3.epa.gov/ozone/science/ods/index.html) shows their ODPs, GWPs, and CAS numbers.	GWPGWPThe index used to translate the level of emissions of various gases into a common measure in order to compare the relative radiative forcing of different gases without directly calculating the changes in atmospheric concentrations. GWPs are calculated as the ratio of the radiative forcing that would result from the emissions of one kilogram of a greenhouse gas to that from the emission of one kilogram of carbon dioxide over a period of time (usually 100 years). Gases involved in complex atmospheric chemical processes have not been assigned GWPs. See lifetime.	ASHRAEASHRAEASHRAE is an international organization that establishes standards for the uniform testing and rating of heating, ventilation, air conditioning, and refrigeration equipment. It also conducts related research, disseminates publications, and provides continuing education to its members. Designation (Safety Classification)	SNAP Listing Date	Use Conditions
FOR12A	FOR12A	R/N	0	1,100	A1	December 18, 2000; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
FOR12B	FOR12B	R/N	0	1,000	A1	December 18, 2000; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
Free Zone (HCFC Blend Delta)	Free Zone/ RB-276	R/N	0.013	1,592	A1	September 5, 1996
Freeze 12	Freeze 12	R/N	0.013	1,606	A1	September 5, 1996
FRIGC FR-12 (HCFC Blend Beta)	FRIGC FR-12	R/N	0.009	1,081	A1	February 8, 1996; February 24, 1998
G2018C	G2018C	R/N	0.053	1,731	A1	September 5, 1996
GHG-HP (HCFC Blend Lambda)	GHG-HP	R/N	0.056	1,893	A1	February 8, 1996
GHG-X4	GHG-X4, Autofrost, Chill-it	R/N	0.045	1,478	A1	September 5, 1996
GHG-X5	GHG-X5	R/N	0.032	2,377	A1	June 3, 1997
HCFC-22	22	R/N	0.055	1,810	A1	March 18, 1994
HCFC-22/HCFC-142b		R/N	0.055-0.065	1,810-2,310	A1	June 3, 1997
HFC-134a	134a	R/N	0	1,430	A1	March 18, 1994; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
Hot Shot	Hot Shot, Kar Kool	R/N	0.098	3,337	A1	September 5, 1996
Hot Shot 2	Hot Shot 2	R	0	1,820	A1	October 4, 2011
Ikon A	Ikon-12, Blend Zeta	R/N	0	N/A	A1	June 19, 2000
Ikon B		R/N	0	N/A	A1	December 6, 1999
R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5)	ICOR AT-22	R/N	0	2,530	A1	March 29, 2006; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-290 (Propane)		N	0	3	A3	April 10, 2015	Detailed conditions apply - see Rule
R-401A	SUVA MP-39	N	0.037	1,182	A1	January 13, 1995
R-401B	SUVA MP-66	N	0.040	1,288	A1	January 13, 1995
R-404A	HP-62	R/N	0	3,920	A1	August 26, 1994; December 20, 2002; July 20, 2015	Unacceptable in retrofit equipment as of July 20, 2016. Unacceptable in new equipment as of January 1, 2019.
R-406A	GHG	R	0.057	1,900	A2	August 26, 1994
R-407C	Suva 407C, Klea 407C	R/N	0	1,770	A1	February 8, 1996; December 20, 2002; August 21, 2003; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-409A (HCFC Blend Gamma)	R-409A (HCFC Blend Gamma)	R	0.047	1,558	A1	August 26, 1994
R-410A	AZ-20, Suva 9100, Puron	N	0	2,090	A1	February 8, 1996; December 20, 2002; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-410B		R/N	0	2,230	A1	February 8, 1996; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-411A		R/N	0.048	1,600	A2	February 8, 1996
R-411B		R/N	0.052	1,700	A2	February 8, 1996
R-417A	ISCEON 59, NU-22	R/N	0	2,350	A1	December 6, 1999; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-420A	Choice R-420A	R/N	0.008	1,536	A1	October 1, 2004
R-421A	Choice R-421A	R/N	0	2,630	A1	September 28, 2006; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-422B	ICOR XAC1, NU-22B	R/N	0	2,530	A1	March 29, 2006; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-422C	ICOR XLT1	R/N	0	3,390	A1	March 29, 2006; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-422D	ISCEON MO29	R/N	0	2,730	A1	September 28, 2006; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-426A	RS-24	R/N	0	1,510	A1	September 28, 2006; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-437A	KDD6, ISCEON MO49 Plus	R/N	0	1,810	A1	January 2, 2009; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-438A	KDD5, ISCEON MO99	R/N	0	2,270	A1	October 4, 2007; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
R-441A		N	0	<5	A3	April 10, 2015	Detailed conditions apply - see Rule
R-450A	Solstice® N-13	R/N	0	601	A1	October 21, 2014; July 16, 2015
R-507, R-507A	AZ-50	R/N	0	3,990	A1	September 5, 1996; December 20, 2002; July 20, 2015	Unacceptable in retrofit equipment as of July 20, 2016. Unacceptable in new equipment as of January 1, 2019.
R-513A	Opteon® XP 10	R/N	0	630	A1	July 16, 2015
R-600a (Isobutane)		N	0	3	A3	April 10, 2015	Detailed conditions apply - see Rule
R-744 (Carbon Dioxide, CO2)		N	0	1	A1	August 10, 2012
RS-24 (2002 formulation)		R/N	0	1,510	A1	December 20, 2002; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
Self-chilling cans using CO2		N	0	1	A1	February 24, 1998
SP34E	SP34E	R/N	0	<1,470	A1	December 18, 2000; June 16, 2010; July 20, 2015	Unacceptable in new equipment as of January 1, 2019.
Stirling Cycle		N	0	N/A	N/A	March 18, 1994; June 16, 2010
THR-02		R/N	0	N/A	A1	December 6, 1999
THR-04		R/N	>0	N/A	A1	June 8, 1999

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