You will need Adobe Reader to view some of the files on this page. See EPA’s About PDF page to learn more.Substitutes are reviewed on the basis of environmental and health risks, including factors such as ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptableacceptableThis designation means that a substitute may be used, without restriction, to replace the relevant ODS within the end-use specified. For example, HCFC-22 is an acceptable substitute for R-502 in industrial process refrigeration. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. and unacceptableUnacceptableThis designation means that it is illegal to use a product as a substitute for an ODS in a specific end-use. For example, HCFC-141b is an unacceptable substitute for CFC-11 in building chillers. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. substitutes are updated several times each year. The list of acceptable substitutes are shown below.

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Substitute	Trade Name	Retrofit/New	ODPODPA number that refers to the amount of ozone depletion caused by a substance. The ODP is the ratio of the impact on ozone of a chemical compared to the impact of a similar mass of CFC-11. Thus, the ODP of CFC-11 is defined to be 1.0. Other CFCs and HCFCs have ODPs that range from 0.01 to 1.0. The halons have ODPs ranging up to 10. Carbon tetrachloride has an ODP of 1.2, and methyl chloroform's ODP is 0.11. HFCs have zero ODP because they do not contain chlorine. A table of all ozone-depleting substances (http://www.epa.gov/ozone/science/ods/index.html) shows their ODPs, GWPs, and CAS numbers.	GWPGWPThe index used to translate the level of emissions of various gases into a common measure in order to compare the relative radiative forcing of different gases without directly calculating the changes in atmospheric concentrations. GWPs are calculated as the ratio of the radiative forcing that would result from the emissions of one kilogram of a greenhouse gas to that from the emission of one kilogram of carbon dioxide over a period of time (usually 100 years). Gases involved in complex atmospheric chemical processes have not been assigned GWPs. See lifetime.	ASHRAEASHRAEASHRAE is an international organization that establishes standards for the uniform testing and rating of heating, ventilation, air conditioning, and refrigeration equipment. It also conducts related research, disseminates publications, and provides continuing education to its members. Designation (Safety Classification)	SNAP Listing Date	Use Conditions
C6 Perfluoroketone	Novec™ 649	R/N	0	0.6 - 1.8	A1	September 30, 2009; June 16, 2010
C7 Fluoroketone	Novec™ 774	R/N	0	1	A1	August 10, 2012
Galden Fluids		R	0	N/A	A1	February 24, 1998
HFC-236fa		R/N	0	9,810	A1	June 8, 1999	When manufactured using any process that does not convert perfluoroisobutylene (PFIB) directly to HFC-236fa in a single step.
HFC-245fa	Genetron® 245fa	R/N	0	1,030	A1	March 29, 2006; June 16, 2010
HFC-4310mee		R/N	0	1,640	A1	June 19, 2000
HFE-7000		R/N	0	575	A1	March 22, 2002; June 16, 2010
HFE-7100		R/N	0	297	A1	June 8, 1999; June 16, 2010	Only acceptable for use as a secondary heat transfer fluid in not-in-kind systems.
HFE-7200		R/N	0	59	N/A	December 18, 2000; June 16, 2010	Only acceptable for use as a secondary heat transfer fluid in not-in-kind systems.
HFO-1234ze	Solstice 1234ze	R/N	0	6	A2L	June 16, 2010
HFO-1336mzz(Z) ((Z)-1,1,1,4,4,4-hexafluorobut-2-ene)	Opteon® MZ	N	0	9	A1	May 23, 2016
Methoxytridecafluoroheptene isomers	MPHE; Sinera™	R/N	0	2.5	A1	July 16, 2015
Mineral Oil		R/N	0	0	N/A	July 28, 1995
PFCs (C3F8, C4F10, C5F12, C5F11NO, C6F14, C6F13NO, C7F16, C7F15NO, C8F18, C8F17NO, C9F21N)		R/N	0	N/A	N/A	N/A	PFCs are only allowed in new systems where a study has demonstrated that no other alternatives are technically feasible due to safety or performance requirements; this study must be kept available for review.
R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5)	ICOR AT-22	R/N	0	2,530	A1	March 29, 2006
R-170 (Ethane)		N	0	5.5	A3	April 10, 2015	Detailed conditions apply - see Rule
R-404A	HP-62	R/N	0	3,920	A1	December 20, 2002
R-407C	Suva 407C, Klea 407C	R/N	0	1,770	A1	December 20, 2002; August 21, 2003
R-410A	AZ-20, Suva 9100, Puron	N	0	2,090	A1	December 20, 2002
R-417A	ISCEON 59, NU-22	R/N	0	2,350	A1	December 6, 1999; June 16, 2010
R-422B	ICOR XAC1, NU-22B	R/N	0	2,530	A1	March 29, 2006
R-422C	ICOR XLT1	R/N	0	3,390	A1	March 29, 2006
R-422D	ISCEON MO29	R/N	0	2,730	A1	September 28, 2006
R-437A	KDD6, ISCEON MO49 Plus	R/N	0	1,810	A1	January 2, 2009
R-438A	KDD5, ISCEON MO99	R/N	0	2,270	A1	October 4, 2007; June 16, 2010
R-507, R-507A	AZ-50	R/N	0	3,990	A1	December 20, 2002
R-744 (Carbon Dioxide, CO2)		R/N	0	1	A1	January 13, 1995; June 16, 2010
Trans-1-chloro-3,3,3-trifluoroprop-1-ene	Solstice 1233zd(E), Solstice N12 Refrigerant	N	0.00024 - 0.00034	4.7 - 7	A1	October 21, 2014
Volatile Methyl Siloxanes		R/N	0	<20	N/A	July 28, 1995; June 16, 2010
Water		R/N	0	N/A	A1	July 28, 1995; June 16, 2010

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