Acceptable Substitutes in Industrial Process Refrigeration
You will need Adobe Reader to view some of the files on this page. See EPA’s About PDF page to learn more.Substitutes are reviewed on the basis of environmental and health risks, including factors such as ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptableacceptableThis designation means that a substitute may be used, without restriction, to replace the relevant ODS within the end-use specified. For example, HCFC-22 is an acceptable substitute for R-502 in industrial process refrigeration. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. and unacceptable
UnacceptableThis designation means that it is illegal to use a product as a substitute for an ODS in a specific end-use. For example, HCFC-141b is an unacceptable substitute for CFC-11 in building chillers. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. substitutes are updated several times each year. The list of acceptable substitutes are shown below.
Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.
Substitute | Trade Name | Retrofit/New | ODP![]() |
GWP![]() |
ASHRAE![]() Designation (Safety Classification) |
SNAP Listing Date | Use Conditions |
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Ammonia Absorption | N | 0 | 0 | B2 | September 5, 1996; June 16, 2010 |
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Ammonia Vapor Compression | N | 0 | 0 | B2 | March 18, 1994; September 5, 1996; June 16, 2010 |
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Chlorine | R/N | N/A | N/A | A1 | March 18, 1994 | ||
Desiccant Cooling | N | 0 | N/A | N/A | March 18, 1994; June 16, 2010 |
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Direct Nitrogen Expansion | N | 0 | 0 | A1 | March 18, 1994; June 16, 2010 |
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Evaporative Cooling | N | 0 | N/A | N/A | March 18, 1994; June 16, 2010 |
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FOR12A | FOR12A | R/N | 0 | 1,100 | A1 | December 18, 2000 | |
FOR12B | FOR12B | R/N | 0 | 1,000 | A1 | December 18, 2000 | |
Free Zone (HCFC Blend Delta) | Free Zone/ RB-276 | R/N | 0.013 | 1,592 | A1 | September 5, 1996 | |
Freeze 12 | Freeze 12 | R/N | 0.013 | 1,606 | A1 | September 5, 1996 | |
FRIGC FR-12 (HCFC Blend Beta) | FRIGC FR-12 | R/N | 0.009 | 1,081 | A1 | February 8, 1996; February 24, 1998 |
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G2018C | G2018C | R/N | 0.053 | 1,731 | A1 | September 5, 1996 | |
GHG-HP (HCFC Blend Lambda) | GHG-HP | R/N | 0.056 | 1,893 | A1 | February 8, 1996 | |
GHG-X4 | GHG-X4, Autofrost, Chill-it | R/N | 0.045 | 1,478 | A1 | September 5, 1996 | |
GHG-X5 | GHG-X5 | R/N | 0.032 | 2,377 | A1 | June 3, 1997 | |
HC Blend B | Original formulation of HC-12a | R/N | 0 | 4 | A3 | January 13, 1995; June 16, 2010 |
|
HC Blend A | OZ-12 | R/N | 0 | 3 | A3 | March 18, 1994; June 16, 2010 |
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HCFC-123 | R/N | 0.02 | 77 | A1 | August 26, 1994 | ||
HCFC-22 | 22 | R/N | 0.055 | 1,810 | A1 | March 18, 1994 | |
HCFC-22/HCFC-142b | R/N | 0.055-0.065 | 1,810-2,310 | A1 | June 3, 1997 | ||
HFC-134a | 134a | R/N | 0 | 1,430 | A1 | March 18, 1994; June 16, 2010 |
|
HFC-134a/HBr (92/8) | N | 0.0016 | N/A | A1 | May 23, 2001 | ||
HFC-227ea | N | 0 | 3,220 | A1 | March 18, 1994; June 16, 2010 |
Manufactured using any process that does not convert perfluoroisobutylene (PFIB) directly to HFC–236fa in a single step | |
HFC-23 | R/N | 0 | 14,800 | A1 | August 26, 1994 | ||
HFC-236fa | R/N | 0 | 9,810 | A1 | March 10, 1997 | ||
HFC-245fa | Genetron® 245fa | R/N | 0 | 1,030 | A1 | March 29, 2006 | |
HFE-7000 | R/N | 0 | 575 | A1 | March 22, 2002; June 16, 2010 |
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HFE-7100 | N | 0 | 297 | A1 | December 18, 2000; June 16, 2010 |
Only acceptable for use as a secondary heat transfer fluid in not-in-kind systems. | |
HFE-7200 | N | 0 | 59 | N/A | December 18, 2000; June 16, 2010 |
Only acceptable for use as a secondary heat transfer fluid in not-in-kind systems. | |
Hot Shot | Hot Shot, Kar Kool | R/N | 0.098 | 3,337 | A1 | September 5, 1996 | |
Hot Shot 2 | Hot Shot 2 | R | 0 | 1,820 | A1 | October 4, 2011 | |
Ikon A | Ikon-12, Blend Zeta | N | 0 | N/A | A1 | June 19, 2000 | |
Ikon B | R/N | 0 | N/A | A1 | December 6, 1999 | ||
NARM-502 | R/N | >0 | N/A | A1 | September 5, 1996 | ||
R-125/R-134a/R-600a (28.1/70.0/1.9) | NU-22 old composition | R/N | 0 | 1,990 | A1 | June 16, 2010 | |
R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5) | ICOR AT-22 | R/N | 0 | 2,530 | A1 | March 29, 2006; June 16, 2010 |
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R-1270 (Propylene) | R/N | 0 | 5 | A3 | March 18, 1994; June 16, 2010 |
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R-290 (Propane) | R/N | 0 | 3 | A3 | March 18, 1994; June 16, 2010 |
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R-401A | SUVA MP-39 | N | 0.037 | 1,182 | A1 | January 13, 1995 | |
R-401B | SUVA MP-66 | N | 0.040 | 1,288 | A1 | January 13, 1995 | |
R-402A | HP-80 | R/N | 0.019 | 2,746 | A1 | March 18, 1994 | |
R-402B | HP-81 | R/N | 0.03 | 2,379 | A1 | March 18, 1994 | |
R-403B | ISCEON 69-L | R/N | 0.041 | 3,096 | A1 | August 26, 1994 | |
R-404A | HP-62 | R/N | 0 | 3,920 | A1 | March 18, 1994; March 22, 2002 |
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R-406A | GHG | R | 0.057 | 1,900 | A2 | August 26, 1994 | |
R-407A | Klea 60, Klea 407A | R/N | 0 | 2,110 | A1 | August 26, 1994; June 16, 2010 |
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R-407B | Klea 61 | R/N | 0 | 2,800 | A1 | August 26, 1994; June 16, 2010 |
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R-407C | Suva 407C, Klea 407C | R/N | 0 | 1,770 | A1 | February 8, 1996; December 20, 2002; August 21, 2003 |
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R-407F | Genetron Performax LT | R/N | 0 | 1,820 | A1 | October 4, 2011 | |
R-408A (HCFC Blend Epsilon) | R | 0.026 | 55 | A1 | August 26, 1994 | ||
R-410A | AZ-20, Suva 9100, Puron | N | 0 | 2,090 | A1 | February 8, 1996; December 20, 2002 |
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R-410B | N | 0 | 2,230 | A1 | February 8, 1996; June 16, 2010 |
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R-411A | R/N | 0.048 | 1,600 | A2 | February 8, 1996 | ||
R-411B | R/N | 0.052 | 1,700 | A2 | February 8, 1996 | ||
R-417A | ISCEON 59, NU-22 | R/N | 0 | 2,350 | A1 | December 6, 1999; December 18, 2000; December 20, 2002; June 16, 2010 |
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R-420A | Choice R-420A | R/N | 0.008 | 1,536 | A1 | October 1, 2004 | |
R-421A | Choice R-421A | R/N | 0 | 2,630 | A1 | September 28, 2006; June 16, 2010 |
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R-421B | Choice R-421B | R/N | 0 | 3,190 | A1 | September 28, 2006; June 16, 2010 |
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R-422A | ISCEON 79 | R/N | 0 | 3,140 | A1 | October 1, 2004 | |
R-422B | ICOR XAC1, NU-22B | R/N | 0 | 2,530 | A1 | March 29, 2006; June 16, 2010 |
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R-422C | ICOR XLT1 | R/N | 0 | 3,390 | A1 | March 29, 2006; June 16, 2010 |
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R-422D | ISCEON MO29 | R/N | 0 | 2,730 | A1 | September 28, 2006; June 16, 2010 |
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R-423A | ISCEON 39TC | R/N | 0 | 2,280 | A1 | March 22, 2002; June 16, 2010 |
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R-424A | RS-44 | R/N | 0 | 2,440 | A1 | September 28, 2006; June 16, 2010 |
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R-426A | RS-24 | R/N | 0 | 1,510 | A1 | September 28, 2006; June 16, 2010 |
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R-427A | Forane 427A | R | 0 | 2,140 | A1 | June 16, 2010 | |
R-428A | RS-52 | N | 0 | 3,610 | A1 | October 4, 2007; June 16, 2010 |
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R-434A | RS-45 | R/N | 0 | 3,250 | A1 | October 4, 2007; June 16, 2010 |
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R-437A | KDD6, ISCEON MO49 Plus | R/N | 0 | 1,810 | A1 | January 2, 2009 | |
R-438A | KDD5, ISCEON MO99 | R/N | 0 | 2,270 | A1 | October 4, 2007; June 16, 2010 |
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R-450A | Solstice® N-13 | R/N | 0 | 601 | A1 | October 21, 2014 | |
R-507, R-507A | AZ-50 | R/N | 0 | 3,990 | A1 | March 18, 1994; September 5, 1996; December 20, 2002 |
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R-508A (PFC Blend Alpha) | Klea 5R3 | R/N | 0 | 13,214 | A1 | July 28, 1995 | |
R-508B | Suva 95 | R/N | 0 | 13,396 | A1 | July 28, 1995 | |
R-513A | Opteon® XP 10 | R/N | 0 | 630 | A1 | July 16, 2015 | |
R-600 (Butane) | R/N | 0 | 3 | A3 | March 18, 1994; June 16, 2010 |
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R-744 (Carbon Dioxide, CO2) | R/N | 0 | 1 | A1 | January 13, 1995; June 16, 2010 |
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RS-24 (2002 formulation) | R/N | 0 | 1,510 | A1 | December 20, 2002; June 16, 2010 |
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RS-44 (2003 formulation) | R/N | 0 | 2,420 | A1 | June 16, 2010 | ||
SP34E | SP34E | R/N | 0 | <1,470 | A1 | December 18, 2000 | |
Stirling Cycle | N | 0 | N/A | N/A | March 18, 1994; June 16, 2010 |
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THR-02 | R/N | 0 | N/A | A1 | December 6, 1999 | ||
THR-03 | R/N | 0 | N/A | A1 | December 6, 1999 | ||
THR-04 | R/N | >0 | N/A | A1 | June 8, 1999 |
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