• Exposure assessment
• General guidance
• Guidance for toxicology testing
• Determining data requirements
• Cumulative exposure and risk assessment

Exposure Assessment

• Standard operating procedures for residential pesticide exposure assessment
• Revised methods for worker risk assessment
• Indirect Dietary Residential Exposure Assessment Model (IDREAM) Implementation 
• Available information on assessing exposure from pesticides in food—A User’s Guide
• Framework for assessing non-occupational, non-dietary (residential) exposure to pesticides

• General principles for performing aggregate exposure and risk assessments

General Guidance

• Determination of the appropriate FQPA safety factor(s) in tolerance assessment
• Choosing a percentile of acute dietary exposure as a threshold of regulatory concern
• Guidance for considering and using open literature studies to support human health risk assessment
• Guidance for waiving or bridging of mammalian acute toxicity tests for pesticides and pesticide products

Guidance for Toxicology Testing

• Advances in genetic toxicology and integration of in vivo testing into standard repeat dose studies
• Use of the local lymph node assay and reduced dose protocol for LLNA in assessing pesticide products
• Process for establishing and implementing alternative approaches to traditional in vivo acute toxicity studies
• Acute oral toxicity up-and-down procedure
• Developing a tiered framework for extrapolation modeling
• Alternate testing framework for classification of eye irritation potential of EPA-regulated pesticide products
• Guidance for thyroid assays in pregnant animals, fetuses and post-natal animals, and adult animals

Determining Data Requirements

• Part 158 toxicology data requirements: guidance for neurotoxicity battery, subchronic inhalation, subchronic dermal and immunotoxicity studies
• Occupational pesticide handler exposure data
• Occupational pesticide post-application exposure data

Cumulative Exposure and Risk Assessment

• Guidance for identifying pesticide chemicals and other substances that have a common mechanism of toxicity
• Guidance on cumulative risk assessment of pesticide chemicals that have a common mechanism of toxicity
• Consideration of the FQPA safety factor and other uncertainty factors in cumulative risk assessment of chemicals sharing a common mechanism of toxicity
• The use of data on cholinesterase inhibition for risk assessments of organophosphorous and carbamate pesticides
• Pesticide Cumulative Risk Assessment: Framework for Screening Analysis