Significant Guidance Documents - Science
This page lists significant guidance documents issued by EPA's Office of the Science Advisor (OSA) or identified as a document for which OSA is the lead office. For every document, you may:
- Comment on the document - Select "Comment" next to the relevant document to go to Regulations.gov, where you can view and comment on it. (Instructions for commenting.)
- Learn more about the document and related EPA programs - Select "Learn More" to go to pages within the EPA Web site that give context to the document.
To browse the documents related to other environmental topics, select from the following list:
You also may comment on how well we are complying with OMB's Good Guidance Bulletin
| Name (ID Number) |
Comment
|
Learn More
|
Issuance Date
|
Date Added to This List
|
Most Recent Revision
|
|---|---|---|---|---|---|
| Alpha2u-Globulin: Association with Chemically Induced Renal Toxicity and Neoplasia in the Male Rat (EPA/625/3-91/019F (NTIS PB92143668)) |
|
09/1991
|
08/23/2007
|
n/a
|
|
| Assessment of Thyroid Follicular Cell Tumors (EPA/630/R-97/002) |
|
03/1998
|
08/23/2007
|
n/a
|
|
| Framework for Application of the Toxicity Equivalence Methodology for Polychlorinated Dioxins, Furans, and Biphenyls in Ecological Risk Assessment (EPA/100/R-08/004) |
06/2008
|
07/15/2008
|
n/a
|
||
| Framework for Cumulative Risk Assessment (EPA/600/P-02/001F) |
|
03/2003
|
08/23/2007
|
n/a
|
|
| Framework for Ecological Risk Assessment (EPA/630/R-92/001) |
|
02/1992
|
08/23/2007
|
n/a
|
|
| Framework for Metals Risk Assessment (EPA/120/R-07/001) |
|
04/2007
|
07/24/2007
|
n/a
|
|
| Generic Ecological Assessment Endpoints (GEAE) for Ecological Risk Assessment (EPA/630/P-02/004F) |
|
10/2003
|
08/23/2007
|
n/a
|
|
| Guidance on Selecting Age Groups for Monitoring and Assessing Childhood Exposures to Environmental Contaminants (EPA/630/P-03/003F) |
|
11/2005
|
08/23/2007
|
n/a
|
|
| Guidelines for Carcinogen Risk Assessment (EPA/630/P-03/001F) |
|
03/2005
|
08/23/2007
|
n/a
|
|
| Guidelines for Developmental Toxicity Risk Assessment (EPA/600/FR-91/001) |
|
12/1991
|
08/23/2007
|
n/a
|
|
| Guidelines for Ecological Risk Assessment (EPA/630/R-95/002F) |
|
04/1998
|
08/23/2007
|
n/a
|
|
| Guidelines for Exposure Assessment (EPA/600/Z-92/001) |
|
05/1992
|
08/23/2007
|
n/a
|
|
| Guidelines for Mutagenicity Risk Assessment (EPA/630/R-98/003) |
09/1986
|
08/23/2007
|
n/a
|
||
| Guidelines for Neurotoxicity Risk Assessment (EPA/630/R-95/001F) |
|
04/1998
|
08/23/2007
|
n/a
|
|
| Guidelines for Reproductive Toxicity Risk Assessment (EPA/630/R-96/009) |
|
10/1996
|
08/23/2007
|
n/a
|
|
| Guidelines for the Health Risk Assessment of Chemical Mixtures (EPA/630/R-98/002) |
|
09/1986
|
08/23/2007
|
n/a
|
|
| Guiding Principles for Monte Carlo Analysis (EPA/630/R-97/001) |
|
03/1997
|
08/23/2007
|
n/a
|
|
| Interim Procedures for Estimating Risks Associated with Exposures to Mixtures of Chlorinated Dibenzo-p-Dioxins and Dibenzofurans (CDDs and CDFs) and 1989 Update (EPA/625/3-89/016 (NTIS PB90145756)) |
03/1989
|
08/23/2007
|
n/a
|
||
| Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures (EPA/630/R-00/002) |
|
08/2000
|
08/23/2007
|
n/a
|
Instructions for Commenting on Documents at Regulations.gov
When you follow the "Comment" links in the table above, you will be directed to the appropriate document details screen on Regulations.gov for the document you are interested in.
You may follow these steps to submit a comment:
- Click on the "Submit Comment" link found above the title of the document. (Note: If you do not see the icon next to "Add Comments," then the action is not currently accepting comments.)
- Fill out the form labeled "Submit a Comment" that appears.
- Review your information.
- When satisfied, click the "Submit" button.