The following are general support documents for the analytical methods program that are not analyte-specific.

• Stability of Pharmaceuticals, Personal Care Products, Steroids, and Hormones in Aqueous Samples, POTW Effluents, and Biosolids (PDF)(43 pp, 371 K, September 2010, 820-R-10-008)
  Also known as "Holding Time Study"
• Quality Assurance and Quality Control Requirements in Methods Not Published by EPA; Memorandum (PDF)(3 pp, 281 K, May 7, 2009)
  This memorandum addresses problems encountered in conducting analyses, or auditing laboratory practices when the QA/QC requirements are sufficient, but published in other parts of an organization's compendium rather than within the Part 136 method; or QA/QC instructions in a Part 136 method are insufficient.
• Solutions to Analytical Chemistry Problems with Clean Water Act Methods (PDF)(65 pp, 1 MB, March 2007, 821-R-07-002)
  Also known as the "Pumpkin Book"
• Method Guidance and Recommendations for Whole Effluent Toxicity (WET) Testing (PDF)(60 pp, 252 K, July 2000, 821-B-00-004)
  Guidance and recommendations on the conduct of the approved WET test methods and interpretation of WET test results reported under the NPDES program
• Guidance on Establishing Trace Metal Clean Rooms in Existing Facilities (Draft) (PDF)(22 pp, 2 MB, January 1996, 821-B-96-001)
  Explains what is optimal and what is acceptable in establishing trace metal clean laboratories within existing facilities. It is based on experience rather than specific engineering designs.