The Physiologically-based Pharmacokinetic (PBPK) Modeling White Paper is in the ninth volume of the series Acute Exposure Guideline Levels for Selected Airborne Chemicals. It describes the methods for integrating physiologically-based pharmacokinetic (PBPK) modeling into the development of AEGLs.  

Chapter 7:  Addressing the Use of PBPK Models to Support Derivation of Acute Exposure Guideline Levels

• Physiologically-Based Pharmacokinetic Modeling White Paper for Acute Exposure Guideline Levels (PDF)(90 pp, 617 K)